Hermans J, Bodart F, François D, Merlo P, Fauconnier J P, Schmitz A, Gérard R, de Ruyver D, Eeckhoudt L
Centre hospitalier Jolimont-Lobbes, 159, rue Ferrer, 7100 La Louvière, Belgique.
Bull Cancer. 2000 Apr;87(4):334-40.
99m Tc MiBi has emerged as a new imaging technique for primary breast carcinomas. The aim of this study was to analyze the diagnostic performance and the additional information provided by scintimammography (SMN). Two hundred and forty consecutive women referred to surgery for abnormalities breast or suspicious breast cancer were scanned before surgery. Sensitivity and specificity were respectively 92% and 53%. PPV: 77.5% and PVN: 79.3%. All false negative scans occurred in cancers 1 cm. SMN detected multiple foci of uptake in the same breast in 13%, that were all confirmed to be multifocal disease and histology. Controlateral focal uptake was also detected; at this time 5/27 are confirmed to be bilateral breast neoplasms; 22 patients are in follow-up. SMN is reliable in the diagnosis of breast cancer and also with difficult cases of mammography. Moreover, SMN provides additional qualitative information in 19.6% of breast carcinomas, such as chest wall infiltration, multifocal or bilateral breast cancer.
99m锝-甲氧基异丁基异腈已成为一种用于原发性乳腺癌的新型成像技术。本研究的目的是分析乳腺闪烁造影（SMN）的诊断性能及所提供的额外信息。对连续240例因乳腺异常或疑似乳腺癌而转诊接受手术的女性患者在手术前进行扫描。敏感性和特异性分别为92%和53%。阳性预测值：77.5%，阴性预测值：79.3%。所有假阴性扫描均出现在直径小于1厘米的癌症中。SMN在13%的病例中检测到同一乳腺内多个摄取灶，所有这些均被证实为多灶性疾病及组织学表现。还检测到对侧局灶性摄取；此时5/27被证实为双侧乳腺肿瘤；22例患者正在随访中。SMN在乳腺癌诊断中是可靠的，对于乳腺钼靶检查的疑难病例也是如此。此外，SMN在19.6%的乳腺癌病例中提供了额外的定性信息，如胸壁浸润、多灶性或双侧乳腺癌。
