利鲁唑治疗的肌萎缩侧索硬化症患者的血压升高。

Blood pressure elevations in riluzole-treated patients with amyotrophic lateral sclerosis.

作者信息

Scelsa S N, Khan I

机构信息

Department of Neurology, Beth Israel Medical Center, New York, NY, USA.

出版信息

Eur Neurol. 2000;43(4):224-7. doi: 10.1159/000008180.

DOI:10.1159/000008180

PMID:10828653

Abstract

OBJECTIVE

To determine whether riluzole is associated with blood pressure elevations in patients with amyotrophic lateral sclerosis (ALS).

BACKGROUND

Though previously reported, hypertension is not considered a frequent adverse effect of riluzole.

METHODS

We reviewed data from 35 consecutive ALS patients on riluzole, and 88 randomly selected controls without and 20 patients with ALS who were not on riluzole.

RESULTS

A significantly greater number of ALS patients on riluzole had blood pressure elevations (28 of 35 patients) compared to controls (26 of 88, p<0.001; 8 of 20, p = 0. 007). Median systolic and diastolic blood pressures were both significantly higher in riluzole-treated (140/86 mm Hg) than in control patients without ALS (120/70 mm Hg, p<0.001). Systolic, but not diastolic, blood pressures were significantly higher in riluzole-treated patients than in controls with ALS (126 mm Hg, p = 0.002).

CONCLUSIONS

Riluzole treatment may be associated with mild blood pressure elevations. Future prospective trials of riluzole should closely assess hypertension.

摘要

目的

确定利鲁唑是否与肌萎缩侧索硬化症（ALS）患者的血压升高有关。

背景

尽管此前有报道，但高血压并不被认为是利鲁唑常见的不良反应。

方法

我们回顾了35例连续使用利鲁唑的ALS患者、88例随机选择的未使用利鲁唑的对照者以及20例未使用利鲁唑的ALS患者的数据。

结果

与对照组（88例中的26例，p<0.001；20例中的8例，p = 0.007）相比，使用利鲁唑的ALS患者中血压升高的人数明显更多（35例中的28例）。接受利鲁唑治疗的患者的收缩压和舒张压中位数（140/86 mmHg）均显著高于未患ALS的对照患者（120/70 mmHg，p<0.001）。接受利鲁唑治疗的患者的收缩压显著高于患ALS的对照患者（126 mmHg，p = 0.002），但舒张压无显著差异。