Kabalka G W, Shoup T M, Daniel G B, Goodman M M
University of Tennessee Biomedical Imaging Center, Knoxville, Tennessee 37996-1600, USA.
Nucl Med Biol. 2000 Apr;27(3):279-87. doi: 10.1016/s0969-8051(99)00100-6.
A series of 17alpha-substituted estradiols was synthesized in which the stereochemical characteristics of carbons 20 and 21 were modified. It was found that the (Z)-isomer demonstrated more favorable receptor binding affinity than the corresponding (E)-isomer.
合成了一系列17α-取代雌二醇，其中对碳20和21的立体化学特征进行了修饰。结果发现，（Z）-异构体比相应的（E）-异构体表现出更有利的受体结合亲和力。
