Klofkorn R W, Steigerwald J C, Mills D M, Smyth C J
Arthritis Rheum. 1976 Mar-Apr;19(2):150-4. doi: 10.1002/art.1780190204.
A case of upper gastrointestinal tract hemorrhage secondary to esophageal varices in a patient with Felty's syndrome prompted a review of the pathogenesis and treatment of this condition. Six previously reported cases of this association were found. The clinical picture is that of long-standing rheumatoid arthritis with severe articular and extraarticular manifestations including splenomegaly, depression of the blood elements, mild liver function abnormalities, portal hypertension without cirrhosis or portal vein obstruction, an elevated splenic blood flow, and a reduction in portal hypertension by simple splenectomy. The presence of portal hypertension with varices may be another indication of splenectomy in patients with Felty's syndrome.
1例费尔蒂综合征患者因食管静脉曲张继发上消化道出血，促使我们对该病的发病机制和治疗进行回顾。发现了6例先前报道的这种关联病例。临床表现为长期类风湿关节炎，伴有严重的关节和关节外表现，包括脾肿大、血细胞减少、轻度肝功能异常、无肝硬化或门静脉阻塞的门静脉高压、脾血流量增加以及单纯脾切除术后门静脉高压降低。门静脉高压伴静脉曲张的存在可能是费尔蒂综合征患者脾切除的另一个指征。
