Chu D, Huttenlocher P R, Levin D N, Towle V L
Fonar Corporation, New York, USA.
Neuropediatrics. 2000 Apr;31(2):63-9. doi: 10.1055/s-2000-7475.
Functional magnetic resonance imaging was used to map the hand somatosensory cortices of nine hemiparetic young adult patients with perinatal unilateral brain injury in the sensorimotor area and five normal subjects. Stimulation of the paretic hand by periodic manual squeezing produced activation in the contralateral hemisphere of three patients and in the ipsilateral hemisphere of three other patients. Paretic hand stimulation produced no activation in either hemisphere of the remaining three patients. Therefore, one-third of the patients demonstrated functional "plasticity" of the brain in the form of inter-hemispheric relocation of the hand somatosensory function. The volume and pattern of activation for both hands was altered for those patients that showed evidence of cortical reorganization to the opposite hemisphere. This differs from the hand motor system, which exhibited inter-hemispheric reorganization in a higher proportion of a related group of hemiparetic subjects.
功能磁共振成像被用于绘制9名围产期单侧脑损伤累及感觉运动区的偏瘫年轻成年患者以及5名正常受试者的手部体感皮层图。通过定期手动挤压刺激瘫痪手，在3名患者的对侧半球以及另外3名患者的同侧半球产生了激活。对其余3名患者的任何一个半球进行瘫痪手刺激均未产生激活。因此，三分之一的患者表现出大脑功能“可塑性”，其形式为手部体感功能在半球间重新定位。对于那些显示出皮层重组至对侧半球证据的患者，双手的激活体积和模式均发生了改变。这与手部运动系统不同，在一组相关的偏瘫受试者中，手部运动系统表现出半球间重组的比例更高。
