Pirillo A, Zhu W, Norata G D, Zanelli T, Barberi L, Roma P, Catapano A L
Institute of Pharmacological Sciences, University of Milano, Italy.
Clin Chem Lab Med. 2000 Feb;38(2):155-60. doi: 10.1515/CCLM.2000.023.
Endothelium is an early target of pro-atherosclerotic events, which may result in functional and morphological perturbations. Oxidized low density lipoproteins, an atherogenic factor with strong cytotoxicity, may potentially contribute to altered endothelial function through the activation of a stress response, which would rescue cells to full vitality, or, conversely, by leading to cell death. Evidence is presented here for the ability of chemically oxidized low density lipoproteins to induce the synthesis of the inducible form of heat shock protein 70 in cultured human endothelial cells, and for the association of epitopes of these modified lipoproteins with apoptotic endothelial cells in aortic sections from hypercholesterolemic rabbits.
内皮是动脉粥样硬化前期事件的早期靶点，这可能导致功能和形态学的扰动。氧化型低密度脂蛋白是一种具有强细胞毒性的致动脉粥样硬化因子，它可能通过激活应激反应来改变内皮功能，这种应激反应要么使细胞恢复全部活力，要么相反，导致细胞死亡。本文提供的证据表明，化学氧化型低密度脂蛋白能够在培养的人内皮细胞中诱导热休克蛋白70诱导型的合成，并且这些修饰脂蛋白的表位与高胆固醇血症兔主动脉切片中的凋亡内皮细胞有关。
