Clarke D L, Johansson C B, Wilbertz J, Veress B, Nilsson E, Karlström H, Lendahl U, Frisén J
Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden.
Science. 2000 Jun 2;288(5471):1660-3. doi: 10.1126/science.288.5471.1660.
The differentiation potential of stem cells in tissues of the adult has been thought to be limited to cell lineages present in the organ from which they were derived, but there is evidence that some stem cells may have a broader differentiation repertoire. We show here that neural stem cells from the adult mouse brain can contribute to the formation of chimeric chick and mouse embryos and give rise to cells of all germ layers. This demonstrates that an adult neural stem cell has a very broad developmental capacity and may potentially be used to generate a variety of cell types for transplantation in different diseases.
成体组织中的干细胞分化潜能一直被认为局限于其来源器官中存在的细胞谱系，但有证据表明一些干细胞可能具有更广泛的分化范围。我们在此表明，成年小鼠大脑中的神经干细胞可参与嵌合鸡和小鼠胚胎的形成，并产生所有三个胚层的细胞。这证明成年神经干细胞具有非常广泛的发育能力，并且有可能用于生成多种细胞类型，以用于不同疾病的移植治疗。
