Bernard B K
Pharmacol Biochem Behav. 1976 Jan;4(1):59-65. doi: 10.1016/0091-3057(76)90176-3.
The effect of testosterone propionate on ranacide (frog-killing) behavior and brain norepinephrine (NE), dopamine (DA) and serotonin (5-HT) levels was determined in 40 female Wistar rats. Adult rats were screened for frog killing behavior on the basis of a single 30 min testing session. Aggressors were defined as animals which attacked or killed during this session while nonaggressors failed to do so. Using either aggressors or nonaggressors, testosterone and sesame oil equally increased aggresive behavior as measured in a second 30 min testing session. Biochemical analyses indicated that testosterone treated animals had significantly higher brain NE and NE/5-HT levels. Aggressors, testosterone or sesame treated had higher NE/5-HT ratios. Whole-brain levels of DA and 5-HT and the DA/5-HT ratios were unaffected. It is concluded that the elicitation of ranacide in the adult female rat is not androgen dependent nor is this behavior functionally related to the observed differences in brain noradrenergic/serotonergic levels. This study provides additional evidence that ranacide is a type of predatory aggression and yet presents data which may be at variance with the classic monoaminergic theory of aggressive behaviors.
在40只雌性Wistar大鼠中测定了丙酸睾酮对杀蛙行为以及脑去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）水平的影响。成年大鼠通过单次30分钟测试筛选杀蛙行为。攻击者定义为在该测试期间攻击或杀死青蛙的动物，而非攻击者则未出现此类行为。使用攻击者或非攻击者，在第二次30分钟测试中，睾酮和芝麻油均同等程度地增加了攻击行为。生化分析表明，接受睾酮处理的动物脑NE水平和NE/5-HT水平显著更高。接受睾酮或芝麻油处理的攻击者具有更高的NE/5-HT比率。全脑DA和5-HT水平以及DA/5-HT比率未受影响。得出的结论是，成年雌性大鼠的杀蛙行为诱发并非雄激素依赖性，且该行为在功能上与观察到的脑去甲肾上腺素能/5-羟色胺能水平差异无关。本研究提供了额外证据表明杀蛙行为是一种捕食性攻击行为，但同时也呈现出可能与经典单胺能攻击行为理论不一致的数据。
