Bernard B K
Natl Inst Drug Abuse Res Monogr Ser. 1975 Nov(3):71-84.
Experiments involving three models of aggression (shock-induced fighting, ranacide and septal lesion-induced hyperirritability) are employed to demonstrate classically different sub-types of aggressive behavior. These categories are shown to be distinct entities when compared on the basis of hormonal dependency, central anatomical and peripheral autonomic involvement and inhibition or enhancement through pharmacological manipulations. Investigations into brain monoamine functioning (norepinephrine, dopamine and serotonin) demonstrate the heterogeneity of correlations which may exist between aggressive behaviors and brain amines. Data are analyzed on the basis of individual amine alterations and changes in monoaminergic neuronal balances. Thus, higher levels of shock-induced aggressive behavior is associated with higher NE/5-HT and DA/K-HT ratioes whereas similar alterations in these biochemical indices occur without observable changes in ranacide behavior. Septal lesion induced hyperirritability is correlated with precisely opposite aminergic changes, namely, decreases in NE/5-HT ratioes. These results demonstrate the necessity of precise aggressive model evaluation prior to attempts at biochemical mechanism elucidation.
涉及三种攻击模型（电击诱导打斗、杀蛙剂和隔区损伤诱导的过度易怒）的实验被用于证明经典的不同攻击行为亚型。当基于激素依赖性、中枢解剖学和外周自主神经参与以及通过药理学操作的抑制或增强进行比较时，这些类别被证明是不同的实体。对脑单胺功能（去甲肾上腺素、多巴胺和5-羟色胺）的研究表明，攻击行为与脑胺之间可能存在的相关性具有异质性。数据根据个体胺变化和单胺能神经元平衡的变化进行分析。因此，电击诱导的攻击行为水平较高与较高的NE/5-HT和DA/K-HT比值相关，而在杀蛙剂行为中这些生化指标有类似变化时却没有可观察到的行为变化。隔区损伤诱导的过度易怒与完全相反的胺能变化相关，即NE/5-HT比值降低。这些结果表明，在试图阐明生化机制之前，精确评估攻击模型是必要的。
