Dll4，一种在动脉内皮中表达的新型Notch配体。
Dll4, a novel Notch ligand expressed in arterial endothelium.
作者信息
Shutter J R, Scully S, Fan W, Richards W G, Kitajewski J, Deblandre G A, Kintner C R, Stark K L
机构信息
Departments of Molecular Genetics, Amgen, Inc., Thousand Oaks, California 91320 USA.
出版信息
Genes Dev. 2000 Jun 1;14(11):1313-8.
Abstract
We report the cloning and characterization of a new member of the Delta family of Notch ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a membrane-bound ligand, characterized by an extracellular region containing several EGF-like domains and a DSL domain required for receptor binding. In situ analysis reveals a highly selective expression pattern of Dll4 within the vascular endothelium. The activity and expression of Dll4 and the known actions of other members of this family suggest a role for Dll4 in the control of endothelial cell biology.
摘要
我们报告了Notch配体Delta家族一个新成员的克隆及特性分析，我们将其命名为Dll4。与其他Delta基因一样，Dll4预计编码一种膜结合配体，其特征是细胞外区域包含几个表皮生长因子（EGF）样结构域以及受体结合所需的DSL结构域。原位分析揭示了Dll4在血管内皮内具有高度选择性的表达模式。Dll4的活性和表达以及该家族其他成员的已知作用表明Dll4在调控内皮细胞生物学过程中发挥作用。
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