Gonda I
Aradigm Corporation, 26219 Eden Landing Road, Hayward, CA, 94545, USA
Adv Drug Deliv Rev. 1998 Jan 5;29(1-2):179-184. doi: 10.1016/s0169-409x(97)00068-9.
This articles reviews the mathematical models of deposition and disposition of drugs administered into the human nasal cavity for systemic activity. The modeling of the disposition kinetics includes drug release from carriers, translocation within the nasal cavity and into the gastrointestinal tract, drug decomposition, and drug absorption during the transit through the nose and the gastrointestinal tract. The uses of such mathematical models for design and analysis of nasal delivery systems are illustrated, with particular reference to the new therapeutic materials and excipients.
本文综述了用于全身活性的药物经鼻腔给药后的沉积和处置的数学模型。处置动力学建模包括药物从载体中的释放、在鼻腔内及进入胃肠道的转运、药物分解以及药物在通过鼻腔和胃肠道过程中的吸收。文中举例说明了此类数学模型在鼻腔给药系统设计和分析中的应用，特别提及了新型治疗材料和辅料。
