支气管哮喘患者的淋巴细胞亚群、血清IgE及嗜酸性粒细胞总数
Lymphocyte subpopulations, serum IgE and total eosinophil counts in patients with bronchial asthma.
作者信息
Gupta S, Frenkel R, Rosenstein M, Grieco M H
出版信息
Clin Exp Immunol. 1975 Dec;22(3):438-45.
Absolute T and B lymphocytes, total eosinophil counts (TEC), and serum IgE levels were studied in twenty-three asthmatic subjects. Compared to a mean peripheral T-lymphocyte count of 1620+/-486/mm3 in twenty control subjects, the mean value in the asthmatic patients was depressed significantly at 1192+/-4 12 (P less than 0-005). T lymphopenia was observed in ten of twenty-three patients (43%). The serum IgE was elevated above the upper limits of 507 mug/ml in six of seventeen patients. TEC above 250/mm3 was observed in twelve of seventeen subjects. T lymphopenia and hyper-immunoglobulinaemia E were each associated with hypereosinophilia. No correlation was observed between T lymphopenia and hyperimmunoglobulinaemia E.
对23名哮喘患者的绝对T淋巴细胞和B淋巴细胞、嗜酸性粒细胞总数（TEC）以及血清IgE水平进行了研究。与20名对照受试者外周血T淋巴细胞平均计数1620±486/mm³相比，哮喘患者的平均值显著降低，为1192±412（P<0.005）。23名患者中有10名（43%）出现T淋巴细胞减少。17名患者中有6名血清IgE升高超过507μg/ml的上限。17名受试者中有12名的TEC高于250/mm³。T淋巴细胞减少和高免疫球蛋白血症E均与嗜酸性粒细胞增多有关。未观察到T淋巴细胞减少与高免疫球蛋白血症E之间的相关性。
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