Hayashi M, Mori Y, Takagi Y, Hoshimoto K, Ohkura T
Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Japan.
Oncology. 2000 May;58(4):300-4. doi: 10.1159/000012116.
Primary small cell neuroendocrine carcinoma of the vagina is extremely rare and very aggressive. Nineteen patients with this cancer have been reported in the English-language literature to date. We report a 51-year-old woman with this cancer. Punch biopsy specimens of the vaginal tumor were studied. Electron microscopy demonstrated neuroendocrine granules in the cytoplasm. Tumor cells were strongly stained for cytokeratin, neuron-specific enolase, chromogranin A and serotonin. These findings were consistent with small cell neuroendocrine carcinoma. The patient was treated with combination chemotherapy. The cancer mass completely disappeared after five cycles of the therapy. The patient is still alive without metastasis 41 months after diagnosis. This is the first report of such a remarkable effect of combination chemotherapy on small cell neuroendocrine carcinoma of the vagina.
原发性阴道小细胞神经内分泌癌极为罕见且侵袭性很强。迄今为止，英文文献中已报道了199919例患有这种癌症的患者。我们报告了一名患有这种癌症的51岁女性。对阴道肿瘤的穿刺活检标本进行了研究。电子显微镜检查显示细胞质中有神经内分泌颗粒。肿瘤细胞对角蛋白、神经元特异性烯醇化酶、嗜铬粒蛋白A和血清素呈强阳性染色。这些发现与小细胞神经内分泌癌相符。该患者接受了联合化疗。经过五个周期的治疗后，癌块完全消失。诊断后41个月，该患者仍然存活且无转移。这是关于联合化疗对阴道小细胞神经内分泌癌产生如此显著疗效的首例报告。
