Rosen A C, Ausch C, Klein M, Graf A H, Metzenbauer M, Philipp K, Reiner A
Department of Obstetrics and Gynaecology, Danube Hospital, SMZ-Ost, Langobardenstrasse 122, A-1220, Vienna, Austria.
Cancer Lett. 2000 Aug 1;156(1):1-7. doi: 10.1016/s0304-3835(00)00335-9.
Sixty-three women treated for primary carcinoma of the fallopian tube (PFTC) from 1980-1995 were retrospectively analyzed to study the impact of p53 expression on survival in primary carcinoma of the fallopian tube. The mean age of the patients was 61.2 years (range 37.3-80.2). Twenty-four (38%) patients were FIGO stage I, 11 (18%) stage II, 19 (30%) stage III and nine (14%) stage IV. Complete radical resection was achieved in 45 (71%) patients. In 56 (89%) women, surgery involved removal of the uterus, the adnexa, and/or the omentum or lymph nodes. Adjuvant therapy consisted of either chemotherapy (n: 31; 49%) or irradiation (n: 21; 33%). The 5-year survival rate for all cases was 43%. For stages I+II and III+IV the 5-year survival rate was 59 and 19%, respectively (P<0.00001). Twelve samples (19%) were p53-negative (tumours with <10% of nuclear staining) and 51 (81%) samples were p53 positive tumours with >10% of nuclear staining. The median survival for the p53-negative group was 40 and 21 months for the p53 positive group. No statistical significance between p53 expression and different FIGO stages was observed, however, a trend for a slightly better survival for the p53-negative group was observed.
对1980年至1995年间接受原发性输卵管癌（PFTC）治疗的63名女性进行回顾性分析，以研究p53表达对原发性输卵管癌生存的影响。患者的平均年龄为61.2岁（范围37.3 - 80.2岁）。24名（38%）患者为国际妇产科联盟（FIGO）I期，11名（18%）为II期，19名（30%）为III期，9名（14%）为IV期。45名（71%）患者实现了根治性切除。56名（89%）女性的手术包括切除子宫、附件和/或大网膜或淋巴结。辅助治疗包括化疗（n = 31；49%）或放疗（n = 21；33%）。所有病例的5年生存率为43%。I + II期和III + IV期的5年生存率分别为59%和19%（P < 0.00001）。12个样本（19%）为p53阴性（核染色<10%的肿瘤），51个样本（81%）为p53阳性肿瘤（核染色>10%）。p53阴性组的中位生存期为40个月，p53阳性组为21个月。未观察到p53表达与不同FIGO分期之间的统计学差异，然而，观察到p53阴性组生存略好的趋势。
