Bassuk J A, Grady R, Mitchell M
Division of Pediatric Urology, Department of Surgery, Children's Hospital and Regional Medical Center, Seattle, Washington, USA.
J Urol. 2000 Jul;164(1):170-9.
To review the crucial role of transgenic mice as experimental tools in the study of outlet obstruction.
We reviewed the literature for studies that have used mice as models for outlet obstruction.
The combination of genetic manipulations and cellular physiology defines state-of-the-art experiments that explore the reciprocal mesenchymal-epithelial interactions that regulate bladder cell mechanisms.
The use of transgenic mice in bladder research has provided important data with respect to the molecular signals that drive bladder development, homeostasis, and the response to injury.
综述转基因小鼠作为实验工具在出口梗阻研究中的关键作用。
我们检索了以小鼠作为出口梗阻模型的相关研究文献。
基因操作与细胞生理学的结合定义了探索调节膀胱细胞机制的相互间间质-上皮相互作用的前沿实验。
在膀胱研究中使用转基因小鼠提供了有关驱动膀胱发育、体内平衡及损伤反应的分子信号的重要数据。
