Coutinho L M, Tarragô R P
Arq Neuropsiquiatr. 1976 Jun;34(2):127-34.
The anatomo-pathological study of ten cases of tuberculosis of the central nervous system (CNS) in children under 10 years old is reported. The emphasis is given to the macroscopic and microscopic changes produced by the tuberculosis in the meninges, in the nervous parenchyma and in the vessels. The clinical and pathological findings are discussed and correlated with the literature. The authors concluded that: 1) the lesion in children with tuberculosis of the CNS is generally a proliferative meningoencephalitis; 2) the nervous parenchyma may be affected by the contiguous propagation of the tuberculous process or by the circulatory changes secondary to the arterial lesions; 3) because of the localization of the endocranial vessels in the sub-arachnoidal space they are generally injured by the inflammatory process, which can determine an obliterating endarteritis, which can be observed by a carotid angiography.
本文报告了10例10岁以下儿童中枢神经系统（CNS）结核的解剖病理学研究。重点关注结核在脑膜、神经实质和血管中产生的宏观和微观变化。对临床和病理结果进行了讨论，并与文献进行了对比。作者得出以下结论：1）中枢神经系统结核患儿的病变通常为增殖性脑膜脑炎；2）神经实质可能受结核病灶的连续扩散影响，或受动脉病变继发的循环变化影响；3）由于颅内血管位于蛛网膜下腔，它们通常会受到炎症过程的损伤，这可能导致闭塞性动脉内膜炎，通过颈动脉血管造影可以观察到。
