Solov'ev V N, Dolgova G V, Murav'eva S A
Farmakol Toksikol. 1975 May-Jun;38(3):354-60.
An inquiry into the nature of antagonism of alpha-tubocurarine and gentamycin to acetylcholine based on a mathematical analysis of cumulative curves obtained in experiments with an isolated musculus rectus abdominalis of the frog showed that the character of changes in the parameters of cumulative curves occuring under the effect of alpha-tubocurarine cannot be explained from the standpoint of Clark's (1929) "employment theory", but accords with deductions drawn from a more general theory of allosteric interaction of substances and receptors (Karlin--1967) in competitive antagonism. Variations in the parameters of cumulation curves occurring under the action of gentamycin may be regarded as a manifestation of non-competative to acetylcholine in conformity with both theories.
基于对青蛙离体腹直肌实验中累积曲线的数学分析，对α-筒箭毒碱和庆大霉素与乙酰胆碱的拮抗作用性质进行的一项研究表明，α-筒箭毒碱作用下累积曲线参数变化的特征无法从克拉克（1929年）的“应用理论”角度进行解释，但符合从物质与受体变构相互作用的更一般理论（卡林，1967年）在竞争性拮抗作用中得出的推论。庆大霉素作用下累积曲线参数的变化，根据这两种理论，都可视为对乙酰胆碱非竞争性作用的一种表现。
