带有2'-S-烷基残基的寡脱氧核糖核苷酸的合成及其对双链稳定性的影响。
Synthesis of oligodeoxyribonucleotide bearing 2'-S-alkyl residue and its effect on the duplex stability.
作者信息
Ozaki H, Sato Y, Azuma S, Sawai H
机构信息
Department of Chemistry, Faculty of Engineering, Gunma University, Japan.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):593-601. doi: 10.1080/15257770008035010.
PMID:10843495
Abstract
2'-Deoxy-2'-S-hexyluridine derivative was synthesized from 2,2'-anhydrouridine and 1-hexanethiol and incorporated into an oligodeoxyribonucleotide. The thermal stability of the duplexes formed by the 2'-S-hexyl modified ODN with either the complementary DNA or RNA strand was decreased compared to the unmodified counterparts.
摘要
2'-脱氧-2'-S-己基尿苷衍生物由2,2'-脱水尿苷和1-己硫醇合成，并掺入到寡脱氧核糖核苷酸中。与未修饰的对应物相比，由2'-S-己基修饰的寡脱氧核苷酸（ODN）与互补DNA或RNA链形成的双链体的热稳定性降低。
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