肾上腺素输注对血管性血友病患者的影响。
The effects of epinephrine infusion in patients with von Willebrand's disease.
作者信息
Rickles F R, Hoyer L W, Rick M E, Ahr D J
出版信息
J Clin Invest. 1976 Jun;57(6):1618-25. doi: 10.1172/JCI108432.
Epinephrine infusion causes variable increases in the components of the Factor VIII (antihemophilic factor) complex in patients with von Willebrand's disease. The increase in antihemophilic factor procoagulant activity was greater than that of Factor VIII-related antigen and von Willebrand factor activity in two patients with von Willebrand's disease. Similar increases in the three individual factors were demonstrated in two other patients. A 4-10-fold increase in Factor VIII-related properties was identified in each of these individuals after infusion. One patient has been studied with very severe von Willebrand's disease; none of the Factor VIII-related properties increased despite two infusions of epinephrine. Bleeding times were normalized or remained normal in the two patients whose von Willebrand factor activity was greater than 25 U/100 ml. It remained prolonged in those three patients whose von Willebrand factor activity levels remained below that concentration. The increase in procoagulant activity was transient in all patients and t 1/2 values were estimated to be between 0.8 and 3.4 h.
肾上腺素输注会使血管性血友病患者的凝血因子 VIII（抗血友病因子）复合物各成分出现不同程度的增加。在两名血管性血友病患者中，抗血友病因子促凝活性的增加大于 VIII 因子相关抗原和血管性血友病因子活性的增加。另外两名患者的这三种单独因子也出现了类似的增加。这些个体在输注后，VIII 因子相关特性均出现了 4 至 10 倍的增加。对一名患有非常严重血管性血友病的患者进行了研究；尽管输注了两次肾上腺素，但 VIII 因子相关特性均未增加。血管性血友病因子活性大于 25 U/100 ml 的两名患者的出血时间恢复正常或保持正常。血管性血友病因子活性水平低于该浓度的三名患者的出血时间仍延长。所有患者的促凝活性增加都是短暂的，半衰期估计在 0.8 至 3.4 小时之间。
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