Kirkeby OJ, Rise IR
Institute for Surgical Research and the Department of Neurosurgery, The National Hospital, University of Oslo, Oslo, Norway
J Clin Neurosci. 1999 Sep;6(5):389-394. doi: 10.1054/jocn.1999.0088.
The aim was to validate intracerebral laser Doppler measurements: a technique with potential applications for studying cerebral microcirculation. A technique for measurements of blood flow from the internal carotid artery was developed and compared to the laser Doppler method in a pig model. Cerebral blood flow was varied using haemorrhage, high cerebrospinal fluid pressure and blood volume expansion. The coefficient of correlation between flow in the carotid artery and laser Doppler flow signals from probes in the cerebral cortex was 0.29 (P<0.005). The correlation improved using relative changes from baseline (coefficient of correlation=0.62, P<0.0001). The highest coefficient of correlation (0.85, P<0.0001) was obtained when blood flow in the right internal carotid artery and laser Doppler flow signal from the corresponding right hemisphere were compared. Laser Doppler flowmetry from intracerebral probes correlates with the internal carotid artery blood flow. Laser Doppler flowmetry from intracerebral probes may provide a simple method for continuous local blood flow measurement in the brain. Copyright 1999 Harcourt Publishers Ltd.
一种在研究脑微循环方面具有潜在应用价值的技术。开发了一种测量颈内动脉血流的技术，并在猪模型中将其与激光多普勒方法进行比较。通过出血、高脑脊液压力和血容量扩充来改变脑血流量。颈动脉血流与大脑皮层中探头的激光多普勒血流信号之间的相关系数为0.29（P<0.005）。使用相对于基线的变化时相关性有所改善（相关系数=0.62，P<0.0001）。当比较右侧颈内动脉的血流与来自相应右半球的激光多普勒血流信号时，获得了最高的相关系数（0.85，P<0.0001）。脑内探头的激光多普勒血流测量与颈内动脉血流相关。脑内探头的激光多普勒血流测量可能为连续局部测量脑血流量提供一种简单方法。版权所有1999年哈考特出版有限公司。
