大分子前药。VIII. 聚合物-吉非贝齐缀合物的合成。
Macromolecular prodrugs. VIII. Synthesis of polymer-gemfibrozil conjugates.
作者信息
Lovrek M, Zorc B, Boneschans B, Butula I
机构信息
Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.
出版信息
Int J Pharm. 2000 Apr 25;200(1):59-66. doi: 10.1016/s0378-5173(00)00340-9.
Abstract
Gemfibrozil is covalently linked to two similar polymers: poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] and poly[alpha,beta-(N-3-hydroxypropyl-DL-aspartamide)]. The synthesised polymer drug conjugates differ in average molecular mass, type of covalent bonding, length of spacer, drug-loading and solubility.
摘要
吉非贝齐与两种相似的聚合物共价连接
聚[α,β-(N-2-羟乙基-DL-天冬酰胺)]和聚[α,β-(N-3-羟丙基-DL-天冬酰胺)]。合成的聚合物药物偶联物在平均分子量、共价键类型、间隔长度、载药量和溶解度方面存在差异。
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