Wilson S E, Page B J, Veomet I C
Lab Anim Sci. 1978 Dec;28(6):728-32.
Following an outbreak of proliferative pneumonia in a guinea pig breeding colony and subsequet treatment with Tylan, a litter of guinea pigs was found to have multiple urogenital and ocular anomalies. Subsequent mating of the parents produced no abnormal offspring. Chromosome typing on the litter showed no abnormalities. A review of normal developmental anatomy and reports of similar anomalies was made in order to elucidate the pathogenesis of the multiple anomalies seen. It was concluded that the teratogenic effect occurred after the formation of the masonephros. The teratogen may have been an infectious agent or the drug Tylan.
在一个豚鼠繁殖群体中爆发增殖性肺炎并随后用泰乐菌素治疗后，一窝豚鼠被发现有多处泌尿生殖和眼部异常。随后亲本交配未产生异常后代。对这窝豚鼠进行染色体分型未发现异常。为阐明所观察到的多种异常的发病机制，对正常发育解剖学和类似异常的报告进行了综述。得出的结论是，致畸作用发生在中肾形成之后。致畸原可能是一种感染因子或药物泰乐菌素。
