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Response of human lymphocytes to mitogenic stimuli after irradiation in vitro.

作者信息

Baral E, Blomgren H

出版信息

Acta Radiol Ther Phys Biol. 1976 Apr;15(2):149-61. doi: 10.3109/02841867609132716.

DOI:10.3109/02841867609132716
PMID:1084674
Abstract

Human lymphocytes were exposed to varying doses of roentgen irradiation in vitro and thereafter tested for reactivity to different polyclonal mitogens and antigens using DNA synthesis as a marker for viability. The dose response profiles obtained indicate that there are two subpopulations of lymphocytes which are responsive to phytohaemagglutinin, poke weed mitogen, concanavalin A and allogeneic cells. One is relatively sensitive to radiation and the other is relatively resistant. However, no "resistant" PPD-tuberculin responsive cell population could be detected. Irradiated lymphocyte populations enriched for T-cells exhibited both a sensitive and a resistant PHA-responsive population, whereas cell populations enriched for B-cells only exhibited a radiation sensitive one.

摘要

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引用本文的文献

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