Palmer A E, London W T, Sly D L, Rice J M
Lab Anim Sci. 1979 Feb;29(1):102-6.
A disease characterized by edema, proteinuria, hypoproteinemia and hypertension was seen in late gestation in patas monkeys. The initial sign was edema of the perineum, ankles and lower trunk. The onset was abrupt, occurring 7 days or less prepartum. The affected animals were not depressed, and convulsions were not seen. In 6 of the 98 pregnancies during a 1-year period, symptoms of the disease were present. The highest incidence was manifested by primiparous animals with 3 of 36 pregnancies affected. Two of 38 second pregnancies and 1 of 24 third pregnancies were also affected. Five of the animals recovered spontaneously and were normal 14 days postpartum. Edema persisted for 30 days in one female. This animal continued to be hypertensive and had persistent mild proteinuria and hypoproteinemia. She was killed approximately 1 year postpartum due to severe renal disease. The spontaneous disease seen in patas monkeys resembled toxemia of pregnancy in humans more closely than the experimentally induced disease in other animals.
在东非狒狒妊娠晚期出现了一种以水肿、蛋白尿、低蛋白血症和高血压为特征的疾病。最初的症状是会阴、脚踝和下腹部水肿。发病突然，发生在产前7天或更短时间内。患病动物没有抑郁症状，也未出现惊厥。在1年期间的98次妊娠中，有6次出现了该病症状。初产动物发病率最高，36次妊娠中有3次受影响。38次第二次妊娠中有2次、24次第三次妊娠中有1次也受影响。5只动物自然恢复，产后14天正常。一只雌性动物的水肿持续了30天。这只动物持续高血压，伴有持续性轻度蛋白尿和低蛋白血症。她在产后约1年因严重肾病死亡。东非狒狒中出现的这种自发性疾病比其他动物实验诱导的疾病更类似于人类的妊娠中毒症。
