Parunović A B, Popović B A
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1976 May 26;199(3):277-9. doi: 10.1007/BF00417298.
In a specially developed experimental model of an infected penetrating eye injury the importance of time and mode of antibiotic administration in the prophylaxis of post-traumatic eye infection was evaluated. It was concluded that the early administration of an antibiotic to which infecting organisms are sensitive can prevent the development of an inflammatory reaction in the majority of injured eyes. The late administration of the same antibiotic (6 h after injury) has no effect at all. Subconjunctival injection was found to be superior to intramuscular if the antibiotic was given at a similar time after injury. The results of this experiment stress the importance of very early antibiotic administration in the prophylaxis of an infection in penetrating eye injuries.
在一个专门建立的感染性穿透性眼外伤实验模型中，评估了抗生素给药时间和方式对预防外伤性眼内感染的重要性。得出的结论是，早期给予感染菌敏感的抗生素可防止大多数受伤眼发生炎症反应。伤后6小时给予相同抗生素则毫无效果。如果在伤后相同时间给予抗生素，结膜下注射优于肌肉注射。该实验结果强调了在预防穿透性眼外伤感染中极早期给予抗生素的重要性。
