间歇性给予甲状旁腺激素对去卵巢大鼠骨折愈合的影响。
Effect of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats.
作者信息
Kim H W, Jahng J S
机构信息
Department of Orthopaedic Surgery, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.
出版信息
Iowa Orthop J. 1999;19:71-7.
Abstract
To evaluate the potential use as a therapeutic agent for osteoporotic fractures, we examined the effects of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats. At three months post-ovariectomy, bilateral tibial shaft fractures were induced and stabilized by intramedullary nailing with Kirschnerwires. Saline, 17-estradiol, or recombinant human PTH(1-84) was given once a day for 30 consecutive days during fracture healing. Fracture healing was assessed by morphometric and mechanical analysis of fracture callus. Intermittent parathyroid hormone administration increased the morphometric and mechanical parameters in a dose-dependent manner. 17-estradiol, a bone-resorption inhibiting agent, did not offer advantage in terms of fracture healing in ovariectomized rats. Our findings suggest that intermittent parathyroid hormone administration may benefit osteoporosis and fracture.
摘要
为评估甲状旁腺激素作为骨质疏松性骨折治疗药物的潜在用途，我们研究了间歇性给予甲状旁腺激素对去卵巢大鼠骨折愈合的影响。在去卵巢术后三个月，通过克氏针髓内钉固定诱导并稳定双侧胫骨干骨折。在骨折愈合期间，连续30天每天给予生理盐水、17-β-雌二醇或重组人甲状旁腺激素（1-84）。通过对骨折痂进行形态计量学和力学分析来评估骨折愈合情况。间歇性给予甲状旁腺激素以剂量依赖方式增加了形态计量学和力学参数。17-β-雌二醇作为一种骨吸收抑制剂，在去卵巢大鼠的骨折愈合方面没有优势。我们的研究结果表明，间歇性给予甲状旁腺激素可能对骨质疏松症和骨折有益。
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