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Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.

作者信息

Rincón M, Flavell R A

机构信息

Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011, USA.

出版信息

Microbes Infect. 1999 Jan;1(1):43-50. doi: 10.1016/s1286-4579(99)80013-6.

DOI:10.1016/s1286-4579(99)80013-6
PMID:10847765
Abstract
摘要

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Reprogramming transcription during the differentiation of precursor CD4+ T cells into effector Th1 and Th2 cells.
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Regulation of the activity of the transcription factors AP-1 and NFAT during differentiation of precursor CD4+ T-cells into effector cells.前体CD4 + T细胞分化为效应细胞过程中转录因子AP-1和NFAT活性的调节。
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Reprogramming the signalling requirement for AP-1 (activator protein-1) activation during differentiation of precursor CD4+ T-cells into effector Th1 and Th2 cells.在前体CD4+ T细胞分化为效应Th1和Th2细胞的过程中，重新编程AP-1（活化蛋白-1）激活的信号需求。
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Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.在转基因小鼠中强制表达GATA-3可抑制Th1分化，并在体内诱导形成表达T1/ST2的Th2定向T细胞区室。
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Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene.转录因子GATA-3在小鼠Th1和Th2细胞中差异表达，并控制白细胞介素-5基因的Th2特异性表达。
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Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice.白细胞介素-4信使核糖核酸稳定性的改变与两种近交系小鼠的1型辅助性T细胞和2型辅助性T细胞偏向以及对过敏性肺炎的易感性相关。
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Neither T-helper type 2 nor Foxp3+ regulatory T cells are necessary for therapeutic benefit of atorvastatin in treatment of central nervous system autoimmunity.他丁类 2 型辅助性 T 细胞和 Foxp3+调节性 T 细胞对于阿托伐他汀治疗中枢神经系统自身免疫的治疗益处均非必需。
J Neuroinflammation. 2014 Feb 6;11:29. doi: 10.1186/1742-2094-11-29.
2
Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity.过氧化物酶体增殖物激活受体（PPAR）α在T细胞中的表达介导了T细胞介导的自身免疫发展中的性别差异。
J Exp Med. 2007 Feb 19;204(2):321-30. doi: 10.1084/jem.20061839. Epub 2007 Jan 29.
3
Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin.
类异戊二烯决定致病性T细胞中的Th1/Th2命运，为阿托伐他汀调节自身免疫提供了一种机制。
J Exp Med. 2006 Feb 20;203(2):401-12. doi: 10.1084/jem.20051129. Epub 2006 Feb 13.
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Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells.白细胞介素-6通过白细胞介素-2依赖和非依赖机制促进新鲜分离的人T细胞产生白细胞介素-4和白细胞介素-5。
Immunology. 2002 Nov;107(3):316-24. doi: 10.1046/j.1365-2567.2002.01501.x.