慢性期慢性髓性白血病异基因骨髓移植后供者来源的费城染色体阳性急性淋巴细胞白血病
A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase.
作者信息
Saito Y, Uzuka Y, Sakai N, Suzuki S, Toyota T
机构信息
The Third Department of Internal Medicine, School of Medicine, Tohoku University, Aobaku, Japan.
出版信息
Bone Marrow Transplant. 2000 Jun;25(11):1209-11. doi: 10.1038/sj.bmt.1702418.
We report here a case of donor cell leukemia in a female Ph-positive CML patient who received an allogeneic BMT from her HLA-identical brother in the chronic phase and subsequently developed a donor cell Ph-positive ALL. The number of cases of donor cell leukemia after BMT so far reported is less than 20 and in this case, as in the first cases reported by Marmont et aland McCane et al, the original leukemia and donor cell leukemia share the presence of a Ph chromosome. Furthermore, we analyzed the patient during different stages of her disease by RT-PCR and determined the type of bcr-abl junctions (M bcr-abl junction; b3a2 transcript, p210) in both the recipient and donor cell leukemia.
我们在此报告一例女性Ph阳性慢性粒细胞白血病（CML）患者发生供体细胞白血病的病例，该患者在慢性期接受了来自其 HLA 相同的兄弟的异基因骨髓移植（BMT），随后发展为供体细胞Ph阳性急性淋巴细胞白血病（ALL）。迄今为止报道的BMT后供体细胞白血病病例数少于20例，在本病例中，如同Marmont等人和McCane等人报道的首例病例一样，原始白血病和供体细胞白血病均存在Ph染色体。此外，我们通过逆转录聚合酶链反应（RT-PCR）在患者疾病的不同阶段对其进行了分析，并确定了受体和供体细胞白血病中bcr-abl连接的类型（M bcr-abl连接；b3a2转录本，p210）。
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