Yüksel A, Cengiz M, Seven M, Ulutin T
Cerrahpaşa Medical Faculty, Istanbul University, GETAM, Turkey.
J Basic Clin Physiol Pharmacol. 2000;11(1):73-81. doi: 10.1515/jbcpp.2000.11.1.73.
This prospective study was carried out to determine changes in the antioxidant system in epileptic children receiving long term antiepileptic drugs (AEDs). Levels of erythrocyte glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and serum lipid peroxidation were determined in 25 healthy children and 30 epileptic children who had not yet received AEDs. Sixteen patients were treated with valproic acid (VPA) and 14 with carbamazepine (CBZ); 13 months later these parameters were retested. The results showed that SOD and lipid peroxidation levels were increased but the GSH-Px levels were decreased in epileptic children on VPA therapy compared with the control group and the results before treatment. No significant differences of these parameters were found in epileptic children on CBZ therapy compared with the control group and the results before treatment, except that lipid peroxidation level was slightly higher in epileptic patients before treatment. We conclude that antioxidant systems in epileptic children on CBZ therapy are better regulated in comparison with epileptic children on VPA therapy.
本前瞻性研究旨在确定长期接受抗癫痫药物（AEDs）治疗的癫痫儿童抗氧化系统的变化。测定了25名健康儿童和30名尚未接受AEDs治疗的癫痫儿童的红细胞谷胱甘肽（GSH）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）水平以及血清脂质过氧化水平。16例患者接受丙戊酸（VPA）治疗，14例接受卡马西平（CBZ）治疗；13个月后对这些参数进行重新检测。结果显示，与对照组及治疗前结果相比，接受VPA治疗的癫痫儿童SOD和脂质过氧化水平升高，但GSH-Px水平降低。与对照组及治疗前结果相比，接受CBZ治疗的癫痫儿童这些参数无显著差异，只是癫痫患者治疗前脂质过氧化水平略高。我们得出结论，与接受VPA治疗的癫痫儿童相比，接受CBZ治疗的癫痫儿童抗氧化系统调节更好。
