Fontalin L N, Novikova T K, Pevnitskiĭ L A, Kondrat'eva I A
Biull Eksp Biol Med. 1976 Mar;81(3):325-7.
Cooperation efficiency of (CBA x C57BL/6) F1 thymocytes and CBA bone marrow cells in immune response to SRBC was compared with the syngenic combination of the same cells. Selectivity of interaction of the T- and B-lymphocytes of different origin was studied in incomplete cyclophosphamines (CBA x C57BL/6) leads to CBA chimerae, where donors were primed with SRBC and the recipients were either intact or tolerant to the given antigen. F1 T-cells proved to interact with the CAB-B-cells 10-15 times less effectively than with the syngenic B-cells. It is suggested that similarity between the antigenic structure of the cell membrane of the T- and B-lymphocytes, aiding their physical contact, increased the action efficiency of the T-mediator on the B-cell.
将（CBA×C57BL/6）F1胸腺细胞与CBA骨髓细胞对SRBC免疫应答的合作效率，与相同细胞的同基因组合进行了比较。在不完全环磷酰胺（CBA×C57BL/6）诱导的CBA嵌合体中，研究了不同来源的T淋巴细胞和B淋巴细胞相互作用的选择性，其中供体用SRBC进行了致敏，受体要么完整，要么对给定抗原有耐受性。结果证明，F1 T细胞与CAB - B细胞相互作用的效率比对同基因B细胞低10 - 15倍。有人提出，T淋巴细胞和B淋巴细胞细胞膜抗原结构之间的相似性有助于它们的物理接触，从而提高了T介质对B细胞的作用效率。
