类风湿关节炎甲氨蝶呤治疗期间出现的原发性皮肤B细胞淋巴瘤
Primary cutaneous B cell lymphoma during methotrexate therapy for rheumatoid arthritis.
作者信息
Fam A G, Perez-Ordonez B, Imrie K
机构信息
Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
出版信息
J Rheumatol. 2000 Jun;27(6):1546-9.
PMID:10852288
Abstract
A patient with rheumatoid arthritis developed a reversible, primary cutaneous, large B cell lymphoma during prolonged methotrexate (MTX) treatment. Regression of the skin lesions after discontinuation of the drug suggested a close relationship to MTX. Increased clinical awareness, discontinuation of MTX, and close observation are important in the initial management of this rare lymphoproliferative disorder.
摘要
一名类风湿性关节炎患者在长期使用甲氨蝶呤（MTX）治疗期间发生了一种可逆的原发性皮肤大B细胞淋巴瘤。停药后皮肤病变消退提示其与MTX密切相关。提高临床意识、停用MTX并密切观察对于这种罕见的淋巴增殖性疾病的初始管理很重要。
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