Kingsmore S F, Hall B D, Allen N B, Rice J R, Caldwell D S
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
J Rheumatol. 1992 Sep;19(9):1462-5.
We describe 2 Caucasian men with rheumatoid arthritis (RA) who developed non-Hodgkin's lymphoma of identical histological type during treatment with low dose oral weekly methotrexate (MTX). Both patients had longstanding RA and had been treated with MTX for over 2 years at time of tumor diagnosis; neither had secondary Sjögren's syndrome. The oncogenic potential of MTX and RA arthritis is reviewed.
我们描述了2名患有类风湿性关节炎（RA）的白种男性，他们在接受低剂量口服每周一次甲氨蝶呤（MTX）治疗期间发生了组织学类型相同的非霍奇金淋巴瘤。两名患者均患有长期RA，在肿瘤诊断时已接受MTX治疗超过2年；两人均无继发性干燥综合征。本文对MTX和RA关节炎的致癌潜力进行了综述。
