Peden D B
Department of Pediatrics and The Center for Environmental Medicine and Lung Biology, The School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Environ Health Perspect. 2000 Jun;108 Suppl 3(Suppl 3):475-82. doi: 10.1289/ehp.00108s3475.
Atopy is a major risk factor for the development of asthma. Immune processes that lead to the development of antigen-specific IgE are essential to the development of atopy. This review examines the immune processes that are candidate targets for modulation by environmental agents; environmental and lifestyle factors that have been suggested as modulators of the development of atopy; and the impact of known environmental agents on atopic processes in the airway. The most important periods of immune development with regard to expression of atopy are likely during gestation and early childhood. A better understanding of which environmental agents are important, as well as the period of life during which these agents may exert an important effect, is essential to devising rational environmental avoidance strategies for at-risk populations.
特应性是哮喘发病的主要危险因素。导致抗原特异性IgE产生的免疫过程对于特应性的发展至关重要。本综述探讨了作为环境因素调节候选靶点的免疫过程;被认为是特应性发展调节因素的环境和生活方式因素;以及已知环境因素对气道特应性过程的影响。就特应性表达而言,免疫发育最重要的时期可能是在妊娠期和幼儿期。更好地了解哪些环境因素很重要,以及这些因素可能发挥重要作用的生命阶段,对于为高危人群制定合理的环境规避策略至关重要。