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父系和母系特应性对围产期IgE产生及哮喘发展的不同影响。

Different implications of paternal and maternal atopy for perinatal IgE production and asthma development.

作者信息

Wu Chih-Chiang, Chen Rong-Fu, Kuo Ho-Chang

机构信息

Department of Pediatrics, Show Chwan Memorial Hospital, 6 Lu-Kung Road, Lu-Kong, Changhua 50544, Taiwan.

出版信息

Clin Dev Immunol. 2012;2012:132142. doi: 10.1155/2012/132142. Epub 2012 Jan 9.

DOI:10.1155/2012/132142
PMID:22272211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3261469/
Abstract

Asthma is a hereditary disease associated with IgE-mediated reaction. Whether maternal atopy and paternal atopy have different impacts on perinatal IgE production and asthma development remains unclear. This paper reviews and summarizes the effects of maternal and paternal atopy on the developmental aspects of IgE production and asthma. Maternal atopy affects both pre- and postnatal IgE production, whereas paternal atopy mainly affects the latter. Maternally transmitted genes GSTP1 and FceRI-beta are associated with lung function and allergic sensitization, respectively. In IgE production and asthma development, the maternal influence on gene-environment interaction is greater than paternal influence. Maternal, paternal, and/or postnatal environmental modulation of allergic responses have been linked to epigenetic mechanisms, which may be good targets for early prevention of asthma.

摘要

哮喘是一种与IgE介导反应相关的遗传性疾病。母亲特应性和父亲特应性对围产期IgE产生及哮喘发展是否有不同影响仍不清楚。本文综述并总结了母亲和父亲特应性对IgE产生及哮喘发展方面的影响。母亲特应性影响产前和产后IgE产生，而父亲特应性主要影响后者。母系遗传基因GSTP1和FceRI-β分别与肺功能和过敏致敏相关。在IgE产生及哮喘发展过程中，母亲对基因-环境相互作用的影响大于父亲。母亲、父亲及/或产后对过敏反应的环境调节与表观遗传机制有关，这可能是早期预防哮喘的良好靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a020/3261469/80308dd15198/CDI2012-132142.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a020/3261469/80308dd15198/CDI2012-132142.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a020/3261469/80308dd15198/CDI2012-132142.001.jpg

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