Barr M, DeSesso J M, Lau C S, Osmond C, Ozanne S E, Sadler T W, Simmons R A, Sonawane B R
Departments of Pediatrics, Pathology and Obstetrics, University of Michigan, Ann Arbor, Michigan, USA.
Environ Health Perspect. 2000 Jun;108 Suppl 3(Suppl 3):569-71. doi: 10.1289/ehp.00108s3569.
The work group on cardiovascular and endocrine effects was asked to review the current state of knowledge about children's windows of vulnerability to developmental toxicants and to recommend how that information may be used to improve risk assessment and public health. We considered differences between structural defects, where periods of vulnerability are rather well defined, and functional defects, where periods of vulnerability are quite elusive.
心血管和内分泌影响工作组被要求审查关于儿童对发育毒物易感性窗口期的现有知识状况,并就如何利用这些信息改进风险评估和公共卫生提出建议。我们考虑了结构缺陷(其易感性时期界定得较为明确)与功能缺陷(其易感性时期相当难以捉摸)之间的差异。