Engelmann I, Bauer G
Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, Germany.
Int J Oncol. 2000 Jul;17(1):97-102.
Serum contains exogenous survival factors for fibroblasts. Removal of these exogenous factors causes inactivation of endogenous survival factors, subsequent release of a constitutively expressed apoptosis machinery from negative control and apoptosis. Inactivation of endogenous survival factors after serum withdrawal is mediated by reactive oxygen species and can be rapidly reversed through re-addition of serum. Oxidative inactivation of endogenous survival factors after depletion of exogenous survival factors as well as the process of reversion to the active state do not require protein synthesis, indicating the existence of a constitutively expressed regulatory system that controls the interaction of exogenous and endogenous survival factors.
血清中含有成纤维细胞的外源性存活因子。去除这些外源性因子会导致内源性存活因子失活，随后从负调控和凋亡中释放出组成性表达的凋亡机制。血清撤除后内源性存活因子的失活由活性氧介导，并且通过重新添加血清可迅速逆转。外源性存活因子耗尽后内源性存活因子的氧化失活以及恢复到活性状态的过程不需要蛋白质合成，这表明存在一个组成性表达的调控系统，该系统控制外源性和内源性存活因子的相互作用。
