Larcan A, Lambert H, Laprevote-Heully M C, Schweitzer M, Gerbaut A
J Gynecol Obstet Biol Reprod (Paris). 1976 Jun;5(4):549-60.
15 patients were referred to the Intensive Care Unit immediately after delivery for severe post-partum haemorrhage. In 7 cases complications followed retroplacental haemotoma formation and in the other 8 cases they were due to secondary haemorrhages from the placental site and/or from tears of the cervix or vagina. It is a clinical picture that is associated with a state of shock, with continuing massive bleeding associated with failure of the blood to clot and which persists and becomes worse with the transfusion of stored blood and of the coagulation factors. In all these cases severe coagulation pathology due to consumption defects is revealed. We must point out that tears of the cervix and vagina which have been neglected and failure to compensate for the original blood loss are among the aetiological factors. Treatment with Heparin giving a dose of 1 to 3 mg per kg of body weight per 24 hours and controlled by a strict biological check together with symptomatic resuscitation from the state of shock and from the coagulation factors is successful (9 cases) if it is undertaken early on. A fatal outcome, whether it is due to a persistent state of shock (1 case) or to visceral complications of diffuse intravascular coagulation (C.I.V.D.) (5 cases) can be found where treatment is delayed and when insufficient blood is replaced and when antifibrinolytics are prescribed. A preventive therapeutic plan as well as a curative one can be drawn up for these cases of obstetrical drama.
15名患者在产后因严重产后出血立即被送往重症监护病房。7例并发症继发于胎盘后血肿形成,另外8例则是由于胎盘部位和/或宫颈或阴道撕裂引起的继发性出血。这是一种与休克状态相关的临床症状,伴有持续大量出血,血液无法凝固,并且在输注库存血和凝血因子后持续存在并恶化。在所有这些病例中,均显示出由于消耗性缺陷导致的严重凝血病理。我们必须指出,宫颈和阴道撕裂被忽视以及未能弥补最初的失血是病因之一。如果早期进行治疗,每24小时给予1至3毫克/千克体重的肝素,并通过严格的生物学检查进行控制,同时对休克状态和凝血因子进行对症复苏,治疗是成功的(9例)。如果治疗延迟、血液置换不足且使用抗纤维蛋白溶解剂,可能会出现致命结果,无论是由于持续休克状态(1例)还是弥漫性血管内凝血(C.I.V.D.)的内脏并发症(5例)。对于这些产科急症病例,可以制定预防性治疗计划和治疗性计划。