Hugo J M, Spence M W, Lickly T D
Dow Chemical Company, Midland, Michigan, USA.
Appl Occup Environ Hyg. 2000 Jun;15(6):512-9. doi: 10.1080/104732200301304.
A study was conducted to assess the ability of polyurethane foam to release toluene diisocyanate (TDI) into the air. The study was completed in two phases. In the first phase, three-day post-production foam samples were "extracted" using 37 degrees C, 30 percent relative humidity air for a total of three days. In the second phase, foam samples were "loaded" with TDI (approximately 1 ppm (w/w) in the foam) by passing air containing a controlled level of TDI vapor through the foam. The "loaded" foam was then aged for three days (to simulate minimum possible expected time between production and consumer contact) before being extracted for three days using 37 degrees C, 30 percent relative humidity air. In both phases of the study, the extracted TDI was quantified by trapping it from the air using glass-fiber filters coated with 1,(2-pyridyl)piperazine (PP) derivatizing agent (modified OSHA Method 42) then analyzing the TDI derivative formed using high-performance liquid chromatography with ultraviolet detection. Validation of the test system was conducted using diffusion-tube-generated TDI atmospheres. Results of the Phase 1 portion of the study showed no quantifiable TDI being extracted from the three-day post-production commercial foam samples at a limit of quantitation of approximately 0.1 ppb TDI in air. Results of the Phase 2 portion of the study showed no quantifiable TDI being extracted from the "loaded" foams at a limit of quantitation of 0.12 microgram TDI (less than 0.03% of the level of TDI loaded into the foams). In conclusion, the results from this study indicate that it is not likely that TDI would be released from three-day post-production polyurethane foams in amounts likely to produce air concentrations of concern.
开展了一项研究，以评估聚氨酯泡沫向空气中释放甲苯二异氰酸酯（TDI）的能力。该研究分两个阶段完成。在第一阶段，使用37摄氏度、相对湿度30%的空气对生产后三天的泡沫样品进行“萃取”，共持续三天。在第二阶段，使含有受控水平TDI蒸汽的空气通过泡沫，从而让泡沫样品“负载”TDI（泡沫中约为1 ppm（w/w））。然后将“负载”的泡沫老化三天（以模拟生产与消费者接触之间的最短预期时间），之后再使用37摄氏度、相对湿度30%的空气进行三天的萃取。在研究的两个阶段中，通过使用涂有1,（2 - 吡啶基）哌嗪（PP）衍生剂的玻璃纤维过滤器从空气中捕获萃取的TDI（改进的OSHA方法42），然后使用带紫外检测的高效液相色谱分析形成的TDI衍生物，对萃取的TDI进行定量。使用扩散管产生的TDI气氛对测试系统进行验证。研究第一阶段部分的结果表明，在空气中TDI定量限约为0.1 ppb时，未从生产后三天的商用泡沫样品中萃取出可定量的TDI。研究第二阶段部分的结果表明，在定量限为0.12微克TDI（低于负载到泡沫中的TDI水平的0.03%）时，未从“负载”的泡沫中萃取出可定量的TDI。总之，该研究结果表明，生产后三天的聚氨酯泡沫不太可能释放出足以产生令人担忧的空气浓度的TDI量。
