Buynak J D, Doppalapudi V R, Rao A S, Nidamarthy S D, Adam G
Department of Chemistry, Southern Methodist University, Dallas, TX 75275-0314, USA.
Bioorg Med Chem Lett. 2000 May 1;10(9):847-51. doi: 10.1016/s0960-894x(00)00094-9.
A series of 2-substituted-7-(alkylidene)cephalosporin sulfones were prepared and evaluated as beta-lactamase inhibitors. Compound 11c showed excellent activity as an inhibitor of the class C beta-lactamase derived from Enterobacter cloacae, strain P99.
