Breydo L, Gates K S
Department of Chemistry, University of Missouri-Columbia, 65211, USA.
Bioorg Med Chem Lett. 2000 May 1;10(9):885-9. doi: 10.1016/s0960-894x(00)00125-6.
Hydrodisulfides (RSSH) have previously been implicated as key intermediates in thiol-triggered oxidative DNA damage by the antitumor agent leinamycin. In an effort to better understand DNA damage by RSSH and to expand on the number and type of chemical systems that produce this reactive intermediate, the ability of 3H-1,2-benzodithiol-3-one 1,1-dioxide (11) to serve as a thiol-dependent DNA cleaving agent has been investigated. The findings reported here indicate that reaction of 11 with thiols results in release of RSSH and subsequent oxidative DNA strand cleavage.
氢二硫化物（RSSH）先前被认为是抗肿瘤药物链黑菌素引发的硫醇触发的氧化性DNA损伤的关键中间体。为了更好地理解RSSH对DNA的损伤作用，并扩展能够产生这种活性中间体的化学体系的数量和类型，人们对3H-1,2-苯并二硫醇-3-酮1,1-二氧化物（11）作为硫醇依赖性DNA切割剂的能力进行了研究。此处报道的研究结果表明，11与硫醇反应会导致RSSH的释放以及随后的氧化性DNA链断裂。
