Tamura S Y, Weinhouse M I, Roberts C A, Goldman E A, Masukawa K, Anderson S M, Cohen C R, Bradbury A E, Bernardino V T, Dixon S A, Ma M G, Nolan T G, Brunck T K
Corvas International, Inc., Department of Medicinal Chemistry, San Diego, CA 92121, USA.
Bioorg Med Chem Lett. 2000 May 1;10(9):983-7. doi: 10.1016/s0960-894x(00)00149-9.
Solid- and solution-phase synthesis of peptidomimetic inhibitors of urokinase-type plasminogen activator based on the sequence dSerAlaArg-al are described. The biological activities of these unique inhibitors are reported herein. Carbonate prodrugs were prepared and tested as potential drug delivery systems.
描述了基于序列dSerAlaArg-al的尿激酶型纤溶酶原激活剂拟肽抑制剂的固相和溶液相合成。本文报道了这些独特抑制剂的生物活性。制备并测试了碳酸酯前药作为潜在的药物递送系统。
