Wolf L, Sheahan M, McCormick J, Michel B, Moskowitz R W
JAMA. 1976 Sep 27;236(13):1497-9.
One hundred healthy women were examined prospectively during their annual physical examination for any of the preliminary criteria of systemic lupus erythematosus (SLE). No patient had more than three of the criteria; 50 (50%) had none. The preliminary criteria were effective in excluding normal patients. Three of 19 patients taking oral contraceptives had serum antinuclear antibody (ANA), whereas only one of 81 non-pill users had serum ANA (P less than .05). None of these patients with positive ANA had clinical evidence of SLE.
对100名健康女性进行了前瞻性研究，在她们年度体检期间检查是否有系统性红斑狼疮（SLE）的任何初步标准。没有患者有超过三项标准；50名（50%）没有任何标准。这些初步标准有效地排除了正常患者。19名服用口服避孕药的患者中有3名血清抗核抗体（ANA）呈阳性，而81名未服用避孕药的使用者中只有1名血清ANA呈阳性（P小于0.05）。这些ANA阳性的患者均无SLE的临床证据。
