Analgesic nephropathy is part of a wider clinical syndrome associated with the abuse of APC compounds, that is, a minimum total intake of 2 kg of aspirin or phenacetin. Ischaemic heart disease and premature aging are newly recognized aspects of the analgesic syndrome. The diagnosis of analgesic nephropathy can be made precisely by the radiological demonstration of renal papillary necrosis. The most important aspect of management of established analgesic nephropathy and renal insufficency is total avoidance of all non-steroid antiinflammatory agents and this is commonly associated with stabilization or improvement in renal function. In the APC mixture, aspirin appears to be the major nephrotoxic agent while phenacetin and paracetamol play a secondary and synergistic role in the nephrotoxicity.
镇痛剂肾病是与滥用复方阿司匹林制剂（即至少摄入2千克阿司匹林或非那西丁）相关的更广泛临床综合征的一部分。缺血性心脏病和早衰是镇痛剂综合征新发现的方面。通过肾乳头坏死的影像学表现可准确诊断镇痛剂肾病。已确诊的镇痛剂肾病和肾功能不全的治疗最重要的方面是完全避免使用所有非甾体抗炎药，这通常与肾功能稳定或改善相关。在复方阿司匹林混合物中，阿司匹林似乎是主要的肾毒性药物，而非那西丁和对乙酰氨基酚在肾毒性中起次要和协同作用。
