Patschan Daniel, Marahrens Benedikt, Matyukhin Igor, Hansen-Nootbaar Henning, Safi Wajima, Ritter Oliver, Patschan Susann
Department of Internal Medicine I - Cardiology, Nephrology and Internal Intensive Medicine, Brandenburg University Hospital, Brandenburg Medical School (Theodor Fontane), 14770 Brandenburg an der Havel, Germany.
J Clin Med Res. 2025 Jul 31;17(7):375-385. doi: 10.14740/jocmr6271. eCollection 2025 Jul.
Chronic kidney disease (CKD) affects an estimated 15% of all adults in Central Europe. Those affected are at high risk of cardiovascular disease and death. Inflammatory rheumatic systemic diseases manifest themselves extra-articularly with varying frequency. This article summarized the prevalence and pathogenetic mechanisms of CKD in rheumatic systemic diseases. The following databases were searched for references: PubMed, Web of Science, Cochrane Library, Scopus. The search period spanned from 1975 to 2025. Kidney involvement is almost always present in systemic lupus erythematosus and certain types of systemic vasculitis. In the context of rheumatic diseases, there are additional mechanisms that can contribute to enhancing the functional and structural integrity of the kidneys. These mechanisms include inflammation and an increase in cardiovascular risk. The prevalence of CKD is disproportionately high in certain entities of the rheumatic form. Given the disproportionately high prevalence of CKD in relevant entities of the inflammatory rheumatic group and the associated increase in the risk of cardiovascular disease and death, CKD screening should be an integral part of the care of affected patients.
据估计，中欧地区15%的成年人患有慢性肾脏病（CKD）。这些患者患心血管疾病和死亡的风险很高。炎症性风湿性全身性疾病会以不同频率在关节外表现出来。本文总结了风湿性全身性疾病中CKD的患病率和发病机制。通过以下数据库检索参考文献：PubMed、科学网、考克兰图书馆、Scopus。检索时间段为1975年至2025年。肾脏受累几乎总是存在于系统性红斑狼疮和某些类型的系统性血管炎中。在风湿性疾病的背景下，还有其他机制可有助于增强肾脏的功能和结构完整性。这些机制包括炎症和心血管风险增加。在某些风湿性疾病实体中，CKD的患病率高得不成比例。鉴于炎症性风湿性疾病组相关实体中CKD的患病率高得不成比例，以及心血管疾病和死亡风险的相应增加，CKD筛查应成为受影响患者护理的一个组成部分。
