陶瓷行业中接触二氧化硅的工人患类风湿性关节炎的情况。
Rheumatoid arthritis in workers exposed to silica in the pottery industry.
作者信息
Turner S, Cherry N
机构信息
Centre for Occupational and Environmental Health, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
出版信息
Occup Environ Med. 2000 Jul;57(7):443-7. doi: 10.1136/oem.57.7.443.
OBJECTIVE
To investigate the relation between rheumatoid arthritis and occupational exposure to silica in pottery and related industries.
METHODS
Medical records of 8325 men and women born 1916-45 and employed in pottery, refractory material (aluminosilicate or silica), and sandstone industries were examined to identify cases of rheumatoid arthritis. Medical and employment histories were extracted for cases and matched referents. Indices of duration, cumulative exposure, and mean silica concentration were compiled. Conditional logistic regression was used to investigate the relation between rheumatoid arthritis and indices of exposure, having allowed for potential confounders of smoking, employment in the coal mining industry, and number of pregnancies.
RESULTS
58 Cases of rheumatoid arthritis (43 men, 15 women) were identified. Cases had significantly shorter duration of exposure than referents. There was no significant difference between cases and referents in mean silica concentration. Men who had worked in the coal mining industry were particularly at risk (odds ratio 5.36, 95% confidence interval 1.92 to 15.03).
CONCLUSION
There was no evidence of increased risk of developing rheumatoid arthritis after occupational exposure to silica at mean exposures within the current United Kingdom exposure limits.
目的
研究类风湿关节炎与陶器及相关行业职业性接触二氧化硅之间的关系。
方法
检查了8325名出生于1916年至1945年且受雇于陶器、耐火材料（铝硅酸盐或二氧化硅）和砂岩行业的男性和女性的医疗记录，以确定类风湿关节炎病例。提取了病例和匹配对照的医疗及就业史。编制了接触时长、累积接触量和二氧化硅平均浓度指数。在考虑了吸烟、煤矿行业就业和怀孕次数等潜在混杂因素后，采用条件逻辑回归研究类风湿关节炎与接触指数之间的关系。
结果
确定了58例类风湿关节炎病例（43名男性，15名女性）。病例的接触时长明显短于对照。病例与对照的二氧化硅平均浓度无显著差异。曾在煤矿行业工作的男性风险尤其高（比值比5.36，95%置信区间1.92至15.03）。
结论
在英国当前接触限值内的平均接触水平下，没有证据表明职业性接触二氧化硅后患类风湿关节炎的风险增加。
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