Akgündüz Bilge
Occupational Diseases Clinic, Eskişehir City Hospital, Eskişehir, Turkey.
Medicine (Baltimore). 2025 Mar 7;104(10):e41702. doi: 10.1097/MD.0000000000041702.
This correlation has been studied since the 1930s, and it is believed that exposure to silica can lead to various autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and systemic sclerosis. The exact mechanisms behind this link remain unclear. This study aimed to evaluate the prevalence of connective tissue diseases (CTD) and positive autoantibodies in pneumoconiosis patients and the association between radiological categorization and autoantibodies. The study included 317 subjects. Pneumoconiosis cases' clinical, radiographic classification, and laboratory results were compared to autoantibody-positive and autoantibody-negative cases, and CTD cases were examined. The prevalence of the CTD in pneumoconiosis was 6%. Sjögren syndrome (n = 5) was the most common disease associated with pneumoconiosis. Autoantibodies were found in 83 (26.2%) pneumoconiosis cases. Antinuclear antibody positivity was highest (n = 75; 23.65%). More than 1 autoantibody was positive in 23 cases (7.25%), while rheumatoid factor was positive in 9 cases (2.84%). It has been shown that autoantibody positivity is 2.79 times higher in cases with category 3 and above pneumoconiosis. The prevalence of CTD and autoantibody positivity associated with pneumoconiosis is higher than in the general population. The presence of autoantibody positivity is associated with advanced pneumoconiosis disease.
自20世纪30年代以来，人们就对这种关联进行了研究，并且认为接触二氧化硅会导致各种自身免疫性疾病，如系统性红斑狼疮、类风湿性关节炎和系统性硬化症。这种关联背后的确切机制仍不清楚。本研究旨在评估尘肺病患者结缔组织病（CTD）和自身抗体阳性的患病率，以及放射学分类与自身抗体之间的关联。该研究纳入了317名受试者。将尘肺病病例的临床、影像学分类和实验室结果与自身抗体阳性和自身抗体阴性病例进行比较，并对CTD病例进行检查。尘肺病中CTD的患病率为6%。干燥综合征（n = 5）是与尘肺病相关的最常见疾病。在83例（26.2%）尘肺病病例中发现了自身抗体。抗核抗体阳性率最高（n = 75；23.65%）。23例（7.25%）病例中有1种以上自身抗体呈阳性，而类风湿因子阳性的有9例（2.84%）。结果显示，3期及以上尘肺病病例的自身抗体阳性率高出2.79倍。与尘肺病相关的CTD和自身抗体阳性的患病率高于一般人群。自身抗体阳性的存在与晚期尘肺病有关。
