Vasama J P, Linthicum F H
House Ear Institute, Los Angeles, California, USA.
Ann Otol Rhinol Laryngol. 2000 Jun;109(6):527-32. doi: 10.1177/000348940010900601.
We microscopically examined the temporal bones of 12 ears with idiopathic sudden sensorineural hearing loss (iSSNHL), 10 ears with presbycusis, 11 ears with normal hearing, and 8 unaffected contralateral ears of patients with iSSNHL. The degeneration of the spiral ligament, vascular stria, hair cells, dendrites, and apical spiral ganglion cells was greater in ears with iSSNHL than in the other groups. The apical ganglion cells were significantly more affected than the basal ganglion cells, and the spiral ganglion cell loss increased as a function of duration of iSSNHL. Cochlear ossification was found in 1 ear with iSSNHL, and hydrops in 2. These findings suggest a viral rather than a vascular or ruptured inner ear membrane origin for iSSNHL.
我们对12例特发性突发性感音神经性听力损失（iSSNHL）患者的颞骨进行了显微镜检查，同时检查了10例老年性聋患者的颞骨、11例听力正常者的颞骨以及8例iSSNHL患者的未受影响的对侧耳。iSSNHL患者耳内的螺旋韧带、血管纹、毛细胞、树突和蜗顶螺旋神经节细胞的退变程度比其他组更严重。蜗顶神经节细胞比蜗底神经节细胞受影响更显著，并且螺旋神经节细胞的损失随着iSSNHL持续时间的延长而增加。在1例iSSNHL患者的耳内发现了耳蜗骨化，2例发现了积水。这些发现提示iSSNHL的病因源于病毒而非血管或内耳膜破裂。
