Bulteau C, Jambaque I, Viguier D, Kieffer V, Dellatolas G, Dulac O
Service de Neuropédiatrie, Hôpital Saint-Vincent-de-Paul, Paris, France.
Dev Med Child Neurol. 2000 May;42(5):319-27. doi: 10.1017/s0012162200000566.
Two-hundred and fifty-one children (98 girls and 153 boys, aged from 3 to 17 years) with documented diagnosis of epileptic syndrome, IQ measurement, and information on school placement were included in this retrospective study. The relations between these three parameters as well as effects of age at onset and duration of epilepsy, seizure frequency, and number of antiepileptic drugs (AEDs) were analysed. Both IQ and schooling were univariately related to epileptic syndrome, age at onset and duration of epilepsy, and number of AEDs; seizure frequency was related to IQ but not to school placement. Multiple regression showed that IQ was independently related to epileptic syndrome and AED; multiple logistic regression showed that type of school (mainstream versus adapted or special) was independently related to IQ and AED. Children with idiopathic generalised or with localisation-related epilepsy had higher IQ scores and higher probability of mainstream schooling than those with symptomatic or cryptogenic generalised epilepsies or epileptic syndromes which were undetermined. Subtests profile of intelligence scale in localisation-related epilepsies showed different specific cognitive deficits, according to the location of the epileptic focus.
本回顾性研究纳入了251名儿童（98名女孩和153名男孩，年龄在3至17岁之间），这些儿童均有癫痫综合征的确诊记录、智商测量结果以及学校安置信息。分析了这三个参数之间的关系，以及发病年龄、癫痫病程、发作频率和抗癫痫药物（AED）数量的影响。智商和学校教育在单因素分析中均与癫痫综合征、发病年龄、癫痫病程以及AED数量相关；发作频率与智商相关，但与学校安置无关。多元回归分析显示，智商与癫痫综合征和AED独立相关；多元逻辑回归分析显示，学校类型（主流学校与适应性或特殊学校）与智商和AED独立相关。与症状性或隐源性全身性癫痫或未明确的癫痫综合征相比，特发性全身性癫痫或局灶性相关性癫痫患儿的智商得分更高，进入主流学校的可能性更大。根据癫痫病灶的位置，局灶性相关性癫痫患儿的智力量表子测试剖面图显示出不同的特定认知缺陷。
