Moomjy M, Mangieri R, Beltramone F, Cholst I, Veeck L, Rosenwaks Z
New York Presbyterian Hospital, New York, New York, USA.
Fertil Steril. 2000 Jun;73(6):1165-9. doi: 10.1016/s0015-0282(00)00539-2.
To assess the efficacy of oocyte donation when a cohort of oocytes is shared between two phenotypically matched recipients.
A retrospective analysis of a program using shared anonymous oocyte donation.
Academic infertility center.
PATIENT(S): Recipient women with partial or complete ovarian failure; oocyte donors who have been properly screened.
INTERVENTION(S): Each oocyte donor was phenotypically matched with two potential recipients. The cohort of donated oocytes were divided between these two recipients if eight or more mature oocytes were obtained at retrieval. Recipients underwent hormone replacement therapy consisting of down-regulation with a GnRH agonist, transdermal estradiol, and intramuscular progesterone in a dose determined by a previous preparatory cycle.
MAIN OUTCOME MEASURE(S): Pregnancy and delivery rates for all transfers originating from a cohort of oocytes obtained by retrieval of a single donor; pregnancy and delivery rates per recipient; rate of conversion of a shared donation cycle to a single recipient.
RESULT(S): A total of 249 donor cycles permitted 241 retrievals. Each recipient received 8.3 +/- 3.5 oocytes per donation. There were 424 fresh ETs and 48 frozen ETs performed. For fresh ETs, clinical pregnancy and ongoing or delivery rates per recipient were 56.8% and 49.7%, respectively. For frozen ETs, these rates were 50% and 39.5%. Implantation rates were 31.8% and 26.1% for fresh and frozen ET, respectively. When analyzed per donor retrieval, clinical pregnancy and ongoing or delivery rates were 109.5% and 95.4%. These high pregnancy rates per donor reflect the numerous fresh and frozen ETs that can result from one donor's retrieval. Conversion of a donation cycle from two recipients to one recipient occurred for 26 of 241 cycles (10.8%).
CONCLUSION(S): Shared anonymous oocyte donation provides a very high pregnancy rate per donor retrieval that is not achievable with unshared donation. In addition, there is a diminished risk exposure of donors per total completed recipient transfers. We support shared oocyte donation as the most efficient use of the precious resource of human oocytes.
评估在一批卵母细胞由两名表型匹配的受者共享时卵母细胞捐赠的效果。
对一项使用共享匿名卵母细胞捐赠项目的回顾性分析。
学术性不孕不育中心。
部分或完全卵巢功能衰竭的受者女性；经过适当筛查的卵母细胞捐赠者。
每个卵母细胞捐赠者与两名潜在受者进行表型匹配。如果取卵时获得8个或更多成熟卵母细胞，则将这批捐赠的卵母细胞在这两名受者之间分配。受者接受激素替代疗法，包括使用GnRH激动剂进行降调节、经皮雌二醇和肌肉注射孕酮，剂量由先前的准备周期确定。
源自单个捐赠者取卵获得的一批卵母细胞的所有移植的妊娠率和分娩率；每个受者的妊娠率和分娩率；共享捐赠周期转换为单个受者的转换率。
总共249个捐赠周期进行了241次取卵。每次捐赠每个受者接受8.3±3.5个卵母细胞。共进行了424次新鲜胚胎移植和48次冷冻胚胎移植。对于新鲜胚胎移植，每个受者的临床妊娠率和持续妊娠或分娩率分别为56.8%和49.7%。对于冷冻胚胎移植，这些比率分别为50%和39.5%。新鲜和冷冻胚胎移植的着床率分别为31.8%和26.1%。按每次捐赠者取卵分析时，临床妊娠率和持续妊娠或分娩率分别为109.5%和95.4%。每个捐赠者的这些高妊娠率反映了一次捐赠者取卵可产生的大量新鲜和冷冻胚胎移植。241个周期中有26个（10.8%）捐赠周期从两名受者转换为一名受者。
共享匿名卵母细胞捐赠每个捐赠者取卵可提供非常高的妊娠率，这是未共享捐赠无法实现的。此外，每个完成的受者移植中捐赠者的风险暴露降低。我们支持共享卵母细胞捐赠作为对人类卵母细胞这一珍贵资源的最有效利用。
