哺乳动物脂肪酸结合蛋白多基因家族：功能的分子与遗传学见解
The mammalian fatty acid-binding protein multigene family: molecular and genetic insights into function.
作者信息
Hertzel A V, Bernlohr D A
机构信息
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Avenue, St Paul, MN 55108, USA.
出版信息
Trends Endocrinol Metab. 2000 Jul;11(5):175-80. doi: 10.1016/s1043-2760(00)00257-5.
Abstract
Intracellular fatty acid-binding proteins associate with fatty acids and other hydrophobic biomolecules in an internal cavity, providing for solubilization and metabolic trafficking. Analyses of their in vivo function by molecular and genetic techniques reveal specific function(s) that fatty acid-binding proteins perform with respect to fatty acid uptake, oxidation and overall metabolic homeostasis.
摘要
细胞内脂肪酸结合蛋白在内部腔室中与脂肪酸及其他疏水性生物分子相结合，从而实现增溶作用及代谢运输。通过分子和基因技术对其体内功能进行分析，揭示了脂肪酸结合蛋白在脂肪酸摄取、氧化及整体代谢稳态方面所发挥的特定功能。
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